Jan Krumsiek

Oct 22, 2024 | alz-journals.onlinelibrary.wiley.com | Richa Batra |Jan Krumsiek |Xue Wang |Mariet Allen

1 BACKGROUND Tau protein hyperphosphorylation and its abnormal accumulation in the brain is a hallmark of several neurodegenerative diseases, including Alzheimer's disease (AD) and progressive supranuclear palsy (PSP).1 The major clinical symptom of AD is dementia, which predominantly impairs memory,2 whereas PSP is a Parkinsonian movement disorder.3 Despite both representing tauopathies, these diseases have several key differences: First, AD is a dual proteinopathy, displaying deposition of...

Aug 19, 2024 | nature.com | Anna Halama |Shaza B. Zaghlool |Gaurav Thareja |Wadha Al Muftah |Sabine Ameling |Maja Pucic Baković | +8 more

AbstractIn-depth multiomic phenotyping provides molecular insights into complex physiological processes and their pathologies. Here, we report on integrating 18 diverse deep molecular phenotyping (omics-) technologies applied to urine, blood, and saliva samples from 391 participants of the multiethnic diabetes Qatar Metabolomics Study of Diabetes (QMDiab).

Jun 11, 2024 | nature.com | Eliah G. Overbey |JangKeun Kim |Braden T. Tierney |Jiwoon Park |Deena Najjar |Remi Klotz | +30 more

AbstractSpaceflight induces molecular, cellular, and physiological shifts in astronauts and poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space1-6. Yet, current frameworks for aerospace medicine are nascent and lag far behind advancements in precision medicine on Earth, underscoring the need for rapid development of space medicine databases, tools, and protocols.

Jun 11, 2024 | nature.com | JangKeun Kim |Eliah G. Overbey |Richa Batra |Annalise Schweickart |Deena Najjar |Cem Meydan | +6 more

AbstractAs spaceflight becomes more common with commercial crews, blood-based measures of crew health can guide both astronaut biomedicine and countermeasures. By profiling plasma proteins, metabolites, and extracellular vesicles/particles (EVPs) from the SpaceX Inspiration4 crew, we generated “spaceflight secretome profiles,” which showed significant differences in coagulation, oxidative stress, and brain-enriched proteins.

Jun 19, 2023 | nature.com | Fengshen Kuo |Mustafa Buyukozkan |Tricia Park |A. Ari Hakimi |Andrew M. Intlekofer |Jan Krumsiek

AbstractTumour metabolism is controlled by coordinated changes in metabolite abundance and gene expression, but simultaneous quantification of metabolites and transcripts in primary tissue is rare. To overcome this limitation and to study gene–metabolite covariation in cancer, we assemble the Cancer Atlas of Metabolic Profiles of metabolomic and transcriptomic data from 988 tumour and control specimens spanning 11 cancer types in published and newly generated datasets.