Nathalie Delgehyr

Dec 30, 2024 | cell.com | Jacques Serizay |Michella Khoury Damaa |Amelie-Rose Boudjema |Remi Balague |Marion Faucourt |Nathalie Delgehyr | +6 more

Keywordscell cycle variantcyclinsAPC/Ccentriolesingle-cell transcriptomicsmulticiliated cellsciliacancermeiosisciliopathiesResearch topic(s)CP: Cell biologyCP: Developmental biologyIntroductionShared factors regulate centriole and DNA duplication processes throughout the cell cycle, and centriole over-duplication is typically associated with genomic instability, accelerating tumor formation and increasing tumor invasiveness (review in Nigg and Holland1).

Dec 10, 2024 | cell.com | Marianne Basso |Alexia Mahuzier |Syed Ali |Anaïs Marty |Marion Faucourt |Ana-Maria Lennon-Duménil | +8 more

Keywordsmulticiliatedependymal celldifferentiationactinnucleusmechanotransductioncell cycleMCIDASretinoblastomaLINC complexIntroductionMulticiliated ependymal cells (ECs) are located along brain ventricles. They form a protective barrier to the brain parenchyma and contribute to cerebrospinal fluid flow through the beating of their motile cilia.1 Impairment of this flow correlates with age-related dementia,2 schizophrenia,3 and hydrocephalus,4 diseases whose onset is not always understood.