Marta Maltese

Aug 8, 2023 | cell.com | Francesco Longo |Paul G. Anastasiades |Marta Maltese |Movement Disorders

Highlights • Altered translation in striatum contributes to repetitive behaviors in FXS mice • Selective deletion of Fmr1 in dSPNs alters translation, causing repetitive behaviors • TRAP-seq shows altered binding of >120 mRNAs to ribosomes in dSPNs of FXS mice • Stimulating the M4 muscarinic receptor reverses repetitive behaviors in FXS mice Summary Individuals with fragile X syndrome (FXS) are frequently diagnosed with autism spectrum disorder (ASD), including increased risk for restricted...