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2 months ago | 
acnr.co.uk | Movement Disorders |Parkinson’s Disease
Researchers from the Cleveland Clinic Genome Center have successfully applied advanced artificial intelligence (AI) genetics models to Parkinson’s disease. Researchers identified genetic factors in progression and FDA-approved drugs that can potentially be repurposed for PD treatment.
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Nov 27, 2024 | 
academic.oup.com | Movement Disorders |Hayriye Cagnan
Essential tremor (ET) is one of the most common movement disorders in adults. Deep brain stimulation (DBS) of the ventralis intermediate nucleus (VIM) of the thalamus and/or the posterior subthalamic area (PSA) has been shown to provide significant tremor suppression in patients with ET, but with significant inter-patient variability and habituation to the stimulation.
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Jul 31, 2024 | 
link.springer.com | Movement Disorders
AbstractFTLD-FET is a newly described subtype of frontotemporal lobar degeneration (FTLD characterized by pathologic inclusions of FET proteins: fused in sarcoma (FUS), Ewing sarcoma, and TATA-binding protein-associated factor 2N (TAF15)). Severe caudate volume loss on MRI has been linked to FTLD-FUS, yet glucose hypometabolism in FTLD-FET has not been studied. We assessed [18F] fluorodeoxyglucose PET (FDG-PET) hypometabolism in FTLD-FET subtypes and compared metabolism to FTLD-tau and FTLD-TDP.
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Jun 13, 2024 | 
academic.oup.com | Movement Disorders
Control of actions allows adaptive, goal-directed behaviour. The basal ganglia, including the subthalamic nucleus, are thought to play a central role in dynamically controlling actions through recurrent negative feedback loops with the cerebral cortex. Here, we summarize recent translational studies that used deep brain stimulation to record neural activity from and apply electrical stimulation to the subthalamic nucleus in people with Parkinson’s disease.
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Jun 10, 2024 | 
link.springer.com | Movement Disorders |Clinical Neuroscience
Parkinson’s disease (PD) diagnosis is based solely on clinical presentation [1]. Therefore, diagnostic and prognostic biomarkers are needed. In recent years, seeding aggregation assays (SAA) have demonstrated the ability to discriminate PD from controls, showing also potential as a predictive marker [2]. Furthermore, the development of modern proteomic techniques such as the proximity extension assay (PEA) has enabled high throughput, highly sensitive multiplexing studies to become more prevalent.
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Jan 20, 2024 | 01419-8/abstract&sz=64)
thelancet.com | Yoav Ben-Shlomo |Sirwan K Darweesh |Movement Disorders |Jorge J. Llibre-Guerra
1. The uses of ‘uses of epidemiology’. Int J Epidemiol. 2001; 30: 1146-11552. Pringsheim T Jette N Frolkis A Steeves TD The prevalence of Parkinson's disease: a systematic review and meta-analysis. Mov Disord. 2014; 29: 1583-15903. Dorsey ER Constantinescu R Thompson JP et al. Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology. 2007; 68: 384-3864. Berg D Postuma RB Bloem B et al. Time to redefine PD?
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Jan 8, 2024 | 
academic.oup.com | Movement Disorders
This scientific commentary refers to ‘Nigrostriatal tau pathology in parkinsonism and Parkinson’s disease’ by Chu et al. (https://doi.org/10.1093/brain/awad388). Mild parkinsonian symptoms in the elderly are widely viewed as a state of vulnerability to disorders involving α-synuclein, tau, amyloid-beta and ischaemic changes. The interest in evaluating this clinical construct rests on the assumption that it represents pre-diagnostic parkinsonism.
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Sep 15, 2023 | 
consultqd.clevelandclinic.org | Movement Disorders
Dual-task training has been shown to enhance gait performance in people with Parkinson’s disease (PD), but it is underutilized due to barriers to implementation. Now a novel digital therapeutic approach to dual-task training (DTT) using augmented reality has shown noninferiority to traditional DTT in improving gait performance in a randomized controlled trial in this population.
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Aug 24, 2023 | 
link.springer.com | Movement Disorders
This is a preview of subscription content, to check access. Final price calculated at checkout. Instant access to the full article PDF. Rent this article via DeepDyve Data availabilityThe data that support the findings of this study are available from the corresponding author upon reasonable request.
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Aug 8, 2023 | 00912-9&sz=64)
cell.com | Francesco Longo |Paul G. Anastasiades |Marta Maltese |Movement Disorders
Highlights • Altered translation in striatum contributes to repetitive behaviors in FXS mice • Selective deletion of Fmr1 in dSPNs alters translation, causing repetitive behaviors • TRAP-seq shows altered binding of >120 mRNAs to ribosomes in dSPNs of FXS mice • Stimulating the M4 muscarinic receptor reverses repetitive behaviors in FXS mice Summary Individuals with fragile X syndrome (FXS) are frequently diagnosed with autism spectrum disorder (ASD), including increased risk for restricted...
