Martin Zhang

Aug 23, 2024 | cell.com | Yoshiaki Yasumizu |Transdisciplinary Research Initiatives |Makoto Kinoshita |Martin Zhang

Highlights•Spatial transcriptomics reveals MG-specific features in the thymus•Multimodal data integration highlights disease association in the medulla•We identify specific immune niches in the medulla and nmTEC enrichment in the junctionSummaryMyasthenia gravis (MG) is etiologically associated with thymus abnormalities, but its pathology in the thymus remains unclear.

Feb 8, 2024 | biorxiv.org | Yoshiaki Yasumizu |Makoto Kinoshita |Martin Zhang |Daisuke Motooka

AbstractMyasthenia gravis (MG) is known to be epidemiologically associated with abnormalities of the thymus, an organ that maintains central tolerance. However, due to the complexity of the thymus, specific characteristics related to the pathogenesis of MG remain elusive. In our study, we attempted to narrow down the features associated with MG using spatial transcriptome analysis of thymoma and thymic hyperplasia samples.

Oct 9, 2023 | nature.com | Xilin Jiang |Martin Zhang |Alkes L Price

AbstractThe analysis of longitudinal data from electronic health records (EHRs) has the potential to improve clinical diagnoses and enable personalized medicine, motivating efforts to identify disease subtypes from patient comorbidity information. Here we introduce an age-dependent topic modeling (ATM) method that provides a low-rank representation of longitudinal records of hundreds of distinct diseases in large EHR datasets.