Matthew Colpus

Aug 12, 2024 | biorxiv.org | William Matlock |Gillian Rodger |Emma Pritchard |Matthew Colpus

AbstractCo-amoxiclav resistance in E. coli is a clinically important phenotype associated with increased mortality. The class A beta-lactamase blaTEM-1 is often carried by co-amoxiclav-resistant pathogens, but exhibits high phenotypic heterogeneity, making genotype-phenotype predictions challenging. We present a curated dataset of n=377 E. coli isolates representing all 8 known phylogroups, where the only acquired beta-lactamase is blaTEM-1.