William Matlock

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Articles

Global genomic epidemiology of bla GES-5 carbapenemase-associated integrons

Dec 4, 2024 | microbiologyresearch.org | William Matlock |Liam Shaw |Nicole Stoesser |Antimicrobial resistance

Article metrics loading... /content/journal/mgen/10.1099/mgen.0.001312Download as PowerPoint /deliver/fulltext/mgen/10/12/mgen001312.html?itemId=/content/journal/mgen/10.1099/mgen.0.001312&mimeType=html&fmt=ahah References Baquero F, Martínez JL, F Lanza V, Rodríguez-Beltrán J, Galán JC et al. Evolutionary pathways and trajectories in antibiotic resistance. Clin Microbiol Rev 2021; 34:e0005019 [View Article] [PubMed][Google Scholar] Sheppard AE, Stoesser N, Wilson DJ, Sebra R, Kasarskis A et al.
Towards quantifying plasmid similarity

Sep 12, 2024 | microbiologyresearch.org | William Matlock |Liam Shaw |Samuel K Sheppard |Edward J Feil

Article metrics loading... /content/journal/mgen/10.1099/mgen.0.001290Download as PowerPoint /deliver/fulltext/mgen/10/9/mgen001290.html?itemId=/content/journal/mgen/10.1099/mgen.0.001290&mimeType=html&fmt=ahah References Coluzzi C, Garcillán-Barcia MP, de la Cruz F, Rocha EPC. Evolution of plasmid mobility: origin and fate of conjugative and nonconjugative plasmids. Mol Biol Evol 2022; 39:msac115 [View Article] [PubMed][Google Scholar] Castañeda-Barba S, Top EM, Stalder T.
E. coli phylogeny drives co-amoxiclav resistance through variable expression of blaTEM-1

Aug 12, 2024 | biorxiv.org | William Matlock |Gillian Rodger |Emma Pritchard |Matthew Colpus

AbstractCo-amoxiclav resistance in E. coli is a clinically important phenotype associated with increased mortality. The class A beta-lactamase blaTEM-1 is often carried by co-amoxiclav-resistant pathogens, but exhibits high phenotypic heterogeneity, making genotype-phenotype predictions challenging. We present a curated dataset of n=377 E. coli isolates representing all 8 known phylogroups, where the only acquired beta-lactamase is blaTEM-1.
Global genomic epidemiology of blaGES-5 carbapenemase-associated integrons

Feb 10, 2024 | biorxiv.org | William Matlock |Liam Shaw |Nicole Stoesser

AbstractAntimicrobial resistance (AMR) gene cassettes comprise an AMR gene flanked by short recombination sites (attI x attC or attC x attC). Integrons are genetic elements able to capture, excise, and shuffle these cassettes, providing 'adaptation on demand', and can be found on both chromosomes and plasmids. Understanding the patterns of integron diversity may help to understand the epidemiology of AMR genes.