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Dec 13, 2024 | 
medium.com | Matthew Du
Dostoevski once wrote:“There is only one thing that I dread: not to be worthy of my sufferings.”In difficult situations, we find an opportunity to prove ourselves worthy of attaining moral values, and our reaction decides whether we are worthy of our sufferings or not.
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Dec 3, 2024 | 
medium.com | Matthew Du |Mehmet Yildiz
Nietszche’s Ubermensch and finding purpose in lifeMatthew Du·FollowPublished inILLUMINATION·4 min read·--Photo by Hiroshi Tsubono on UnsplashFriedrich Nietszche once said:He who has a why can bear any how. He emphasized the power of purpose and meaning in life. So, if a person knows why they are enduring a hardship or suffering, then they can find the strength to cope with extreme adversity. Naturally, you then ask: how do you find your why? Humans are naturally great at complaining.
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Dec 2, 2024 | 
medium.com | Matthew Du
This mental model helped him solve all his problems. Matthew Du·Follow3 min read·--Credits: The New York TimesCharlie Munger is worth USD 2.6 billion. He built this wealth by rationally investing in undervalued companies. Obviously, much of his wealth can be credited to his skill and knowledge in investing in the markets — but how he built those skills is almost as important.
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Nov 21, 2024 | 
medium.com | Matthew Du |Mehmet Yildiz
Matthew Du·FollowPublished inILLUMINATION·5 min read·--And so, based on empirical evidence, we can only conclude that “follow your passion” is horrible career advice. Like so many others, Steve Jobs was my primary influence for chasing my passion. In 2005, Stanford invited Steve Jobs to speak at the university’s 114th Commencement. Drawing from some of the most pivotal points in his life, Steve Jobs taught core lessons on jumping at opportunities.
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Aug 28, 2024 | 
science.org | Matthew Du |Reo Higashi |Rebekah A. Warwick |Ian MacArthur
AbstractDNA methylation is extensively reconfigured during development, but the functional significance and cell type–specific dependencies of DNA demethylation in lineage specification remain poorly understood. Here, we demonstrate that developmental DNA demethylation, driven by ten-eleven translocation 1/2/3 (TET1/2/3) enzymes, is essential for establishment of neural stem cell (NSC) identity and gliogenic potential.
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Aug 28, 2024 | 
science.org | Matthew Du |Reo Higashi |Rebekah A. Warwick |Liang Xu
AbstractCold stress, a prominent adverse environmental factor, severely hinders rice growth and productivity. Unraveling the complex mechanisms governing chilling tolerance in rice is crucial for molecular breeding of cold-tolerant varieties. Here, we identify an APETALA2/Ethylene Responsive Factor (AP2/ERF) transcription factor, OsERF52, as a positive modulator in response to low temperatures. OsERF52 directly regulates the expression of C-Repeat Binding Factor (CBF) genes in rice.
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Aug 28, 2024 | 
science.org | Matthew Du |Reo Higashi |Rebekah A. Warwick |Masato Morita
AbstractThe processing of synaptic signals in somatodendritic compartments determines neuronal computation. Although the amplification of excitatory signals by local voltage-dependent cation channels has been extensively studied, their spatiotemporal dynamics in elaborate dendritic branches remain obscure owing to technical limitations.
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Aug 28, 2024 | 
science.org | Matthew Du |Reo Higashi |Rebekah A. Warwick |Tao Yu
AbstractMicroglia, the crucial immune cells inhabiting the central nervous system (CNS), perform a range of vital functions, encompassing immune defense and neuronal regulation. Microglia subsets with diverse functions and distinct developmental regulations have been identified recently.
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Aug 28, 2024 | 
science.org | Matthew Du |Reo Higashi |Rebekah A. Warwick |Tinghua Zhang
AbstractThe complex anatomy of internal luminal organs, like bronchioles, poses challenges for endoscopic optical coherence tomography (OCT). These challenges include limited steerability for targeted imaging and nonuniform rotation distortion (NURD) with proximal scanning. Using rotary micromotors for distal scanning could address NURD but raises concerns about electrical safety and costs.
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Aug 28, 2024 | 
science.org | Matthew Du |Reo Higashi |Rebekah A. Warwick |Changsheng Li
AbstractStrigolactones exhibit dual functionality as regulators of plant architecture and signaling molecules in the rhizosphere. The important model crop rice exudes a blend of different strigolactones from its roots. Here, we identify the inaugural noncanonical strigolactone, 4-oxo-methyl carlactonoate (4-oxo-MeCLA), in rice root exudate.
