Reo Higashi

Aug 28, 2024 | science.org | Matthew Du |Reo Higashi |Rebekah A. Warwick |Ian MacArthur

AbstractDNA methylation is extensively reconfigured during development, but the functional significance and cell type–specific dependencies of DNA demethylation in lineage specification remain poorly understood. Here, we demonstrate that developmental DNA demethylation, driven by ten-eleven translocation 1/2/3 (TET1/2/3) enzymes, is essential for establishment of neural stem cell (NSC) identity and gliogenic potential.

Aug 28, 2024 | science.org | Matthew Du |Reo Higashi |Rebekah A. Warwick |Liang Xu

AbstractCold stress, a prominent adverse environmental factor, severely hinders rice growth and productivity. Unraveling the complex mechanisms governing chilling tolerance in rice is crucial for molecular breeding of cold-tolerant varieties. Here, we identify an APETALA2/Ethylene Responsive Factor (AP2/ERF) transcription factor, OsERF52, as a positive modulator in response to low temperatures. OsERF52 directly regulates the expression of C-Repeat Binding Factor (CBF) genes in rice.

Aug 28, 2024 | science.org | Matthew Du |Reo Higashi |Rebekah A. Warwick |Masato Morita

AbstractThe processing of synaptic signals in somatodendritic compartments determines neuronal computation. Although the amplification of excitatory signals by local voltage-dependent cation channels has been extensively studied, their spatiotemporal dynamics in elaborate dendritic branches remain obscure owing to technical limitations.

Aug 28, 2024 | science.org | Matthew Du |Reo Higashi |Rebekah A. Warwick |Tao Yu

AbstractMicroglia, the crucial immune cells inhabiting the central nervous system (CNS), perform a range of vital functions, encompassing immune defense and neuronal regulation. Microglia subsets with diverse functions and distinct developmental regulations have been identified recently.

Aug 28, 2024 | science.org | Matthew Du |Reo Higashi |Rebekah A. Warwick |Tinghua Zhang

AbstractThe complex anatomy of internal luminal organs, like bronchioles, poses challenges for endoscopic optical coherence tomography (OCT). These challenges include limited steerability for targeted imaging and nonuniform rotation distortion (NURD) with proximal scanning. Using rotary micromotors for distal scanning could address NURD but raises concerns about electrical safety and costs.