Matthew R. Thau

May 24, 2024 | digitalcommons.library.tmc.edu | Matthew R. Thau |Ted Liu |Neha A Sathe |Grant O'Keefe

IMPORTANCE: It is not clear which severely injured patients with hemorrhagic shock may benefit most from a 1:1:1 vs 1:1:2 (plasma:platelets:red blood cells) resuscitation strategy. Identification of trauma molecular endotypes may reveal subgroups of patients with differential treatment response to various resuscitation strategies.

Apr 26, 2023 | jamanetwork.com | Matthew R. Thau |Ted Liu |Grant O’Keefe

Key PointsQuestion  Are trauma molecular endotypes associated with clinical outcomes and differential response to transfusion resuscitation strategies? Findings  In this secondary analysis of the Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) trial including 478 patients, 2 molecular endotypes of trauma patients were identified using a panel of 36 plasma biomarkers collected at the time of hospital arrival.