Matthias Kretzler

Jul 19, 2023 | nature.com | Seth Winfree |Qiwen Hu |Ricardo Melo Ferreira |Daria Barwinska |fei chen |Sushrut S. Waikar | +12 more

Statistics and reproducibilityFor 3D imaging and immunofluorescence staining experiments, each staining was repeated on at least two separate individuals or separate regions. For immunofluorescence validation studies, commercially available antibodies were used; 13 out of the 15 tissue samples were also analysed using snCv3 or scCv3. For ISH, 6 tissue samples (4 biopsies and 2 nephrectomies) were analysed.

Mar 1, 2023 | jci.org | Katherine R. Tuttle |Jennifer Schaub |Matthias Kretzler |Petter Bjornstad

AbstractThe sodium-glucose cotransporter-2 (SGLT2) is expressed on the luminal side of proximal tubule epithelial cells in the kidney. While pharmacological inhibition of SGLT2 provides kidney protection in diabetic kidney disease (DKD), the molecular mechanisms remain unclear. In this issue of the JCI, Schaub et al. report on the changes in single-cell transcriptional profiles of young participants with type 2 diabetes who received SGLT2 inhibitors.