Matthieu Gautier

Dec 2, 2024 | nature.com | Jordan W. Squair |Viviana Aureli |Nicholas James |Laetitia Baud |Michael A. Skinnider |Matthieu Gautier | +12 more

AbstractA spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after incomplete SCI and that could be targeted to augment this recovery.

Jun 20, 2024 | inria.hal.science | Matthieu Gautier |Alice Chillet |Robin Gerzaguet |Karol Desnos

Communication Dans Un Congrès Année : 2024 How to Design Channel-Resilient Database for Radio Frequency Fingerprint Identification? Mots clés Deep Learning Radio Frequency Fingerprint RF impairments models Origine Fichiers produits par l'(les) auteur(s) hal-04617952 , version 1 (20-06-2024) HAL Id : hal-04617952 , version 1 Alice Chillet, Robin Gerzaguet, Karol Desnos, Matthieu Gautier, Elena Simona Lohan, et al..

Jun 19, 2024 | nature.com | Michael A. Skinnider |Matthieu Gautier |Claudia Kathe |Thomas Hutson |Achilleas Laskaratos |Viviana Aureli | +7 more

AbstractHere, we introduce the Tabulae Paralytica—a compilation of four atlases of spinal cord injury (SCI) comprising a single-nucleus transcriptome atlas of half a million cells, a multiome atlas pairing transcriptomic and epigenomic measurements within the same nuclei, and two spatial transcriptomic atlases of the injured spinal cord spanning four spatial and temporal dimensions.

Jun 13, 2024 | biorxiv.org | Matthieu Gautier |Laurent Brock |Jennifer Tsai |Alexandra de Coucy

AbstractWe introduce Vespucci, a machine-learning method to identify perturbation-responsive regions, genes and gene programs within comparative spatial transcriptomics atlases. We validate Vespucci on simulated and published datasets and show that it outperforms 19 published computational methods for spatial transcriptomics. We apply Vespucci to expose the spatial organization of gene programs activated by therapies that guide repair of the injured spinal cord.

May 8, 2024 | biorxiv.org | Matthieu Gautier |Jan Elaine Soriano |Remi Hudelle |Lois Mahe

AbstractAutonomic dysreflexia is a life-threatening medical condition characterized by episodes of uncontrolled hypertension that occur in response to sensory stimuli after spinal cord injury (SCI). The fragmented understanding of the mechanisms underlying autonomic dysreflexia hampers the development of therapeutic strategies to manage this condition, leaving people with SCI at daily risk of heart attack and stroke.