Claudia Kathe

Dec 2, 2024 | nature.com | Jordan W. Squair |Viviana Aureli |Nicholas James |Laetitia Baud |Michael A. Skinnider |Matthieu Gautier | +12 more

AbstractA spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after incomplete SCI and that could be targeted to augment this recovery.

Sep 26, 2024 | science.org | Qiuhe Lu |Z. Chahine |J. G. Muir |Claudia Kathe

Walking is seemingly effortless for most of us. We walk, run, and climb stairs without consciously thinking about each step. However, these simple movements require a highly complex interplay of muscle activations that consists of left-right leg alternation, coordinated muscle co-contractions, and inhibition of antagonistic muscle contractions. Even more fascinating is that stepping can be generated without any communication between the brain and the spinal cord.

Jun 19, 2024 | nature.com | Michael A. Skinnider |Matthieu Gautier |Claudia Kathe |Thomas Hutson |Achilleas Laskaratos |Viviana Aureli | +7 more

AbstractHere, we introduce the Tabulae Paralytica—a compilation of four atlases of spinal cord injury (SCI) comprising a single-nucleus transcriptome atlas of half a million cells, a multiome atlas pairing transcriptomic and epigenomic measurements within the same nuclei, and two spatial transcriptomic atlases of the injured spinal cord spanning four spatial and temporal dimensions.

Jun 24, 2023 | biorxiv.org | Michael A. Skinnider |Matthieu Gautier |Claudia Kathe |Thomas Hutson

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