Jordan W. Squair

Dec 2, 2024 | nature.com | Jordan W. Squair |Viviana Aureli |Nicholas James |Laetitia Baud |Michael A. Skinnider |Matthieu Gautier | +12 more

AbstractA spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after incomplete SCI and that could be targeted to augment this recovery.

Oct 11, 2024 | nature.com | Jordan W. Squair |Grégoire Courtine

AbstractDifferential accessibility (DA) analysis of single-cell epigenomics data enables the discovery of regulatory programs that establish cell type identity and steer responses to physiological and pathophysiological perturbations. While many statistical methods to identify DA regions have been developed, the principles that determine the performance of these methods remain unclear.

Jun 19, 2024 | nature.com | Michael A. Skinnider |Matthieu Gautier |Claudia Kathe |Thomas Hutson |Achilleas Laskaratos |Viviana Aureli | +7 more

AbstractHere, we introduce the Tabulae Paralytica—a compilation of four atlases of spinal cord injury (SCI) comprising a single-nucleus transcriptome atlas of half a million cells, a multiome atlas pairing transcriptomic and epigenomic measurements within the same nuclei, and two spatial transcriptomic atlases of the injured spinal cord spanning four spatial and temporal dimensions.

May 20, 2024 | nature.com | Chet Moritz |Edelle C Field-Fote |Ilse van Nes |Andrei V. Krassioukov |James Guest |Jared Pradarelli | +1 more

AbstractCervical spinal cord injury (SCI) leads to permanent impairment of arm and hand functions. Here we conducted a prospective, single-arm, multicenter, open-label, non-significant risk trial that evaluated the safety and efficacy of ARCEX Therapy to improve arm and hand functions in people with chronic SCI. ARCEX Therapy involves the delivery of externally applied electrical stimulation over the cervical spinal cord during structured rehabilitation.

Sep 21, 2023 | science.org | Sergiy Kalnaus |Connor A Horton |Jun Cheng |Jordan W. Squair

Published In ScienceVolume 381 | Issue 666422 September 2023Article versionsSubmission historyReceived: 9 May 2023Accepted: 18 August 2023Published in print: 22 September 2023PermissionsRequest permissions for this article.