Mehdi Benamar

Jan 22, 2025 | nature.com | Emmanuel Stephen-Victor |Gavin A. Kuziel |Mehdi Benamar |Jason Fong |Kari C. Nadeau |David Breault | +2 more

AbstractTolerance to dietary antigens is critical for avoiding deleterious type 2 immune responses resulting in food allergy (FA) and anaphylaxis1,2. However, the mechanisms resulting in both the maintenance and failure of tolerance to food antigens are poorly understood. Here we demonstrate that the goblet-cell-derived resistin-like molecule β (RELMβ)3,4 is a critical regulator of oral tolerance. RELMβ is abundant in the sera of both patients with FA and mouse models of FA.