Melanie Horn

Sep 23, 2024 | biorxiv.org | Thomas Naert |Taiyo Yamamoto |Shuting Han |Melanie Horn

AbstractCRISPR-based genome engineering holds enormous promise for basic science and therapeutic applications. Integrating and editing DNA sequences is still challenging in many cellular contexts, largely due to insufficient control of the repair process. We find that repair at the genome-cargo interface is predictable by deep-learning models and adheres to sequence context specific rules.