Melanie Weisser

Mar 18, 2024 | nature.com | Melanie Weisser |Andreas Mund |Blanca Lopez Mendez |Ivo A. Hendriks |Michael Nielsen |Hemmo Meyer | +2 more

AbstractThe hexameric AAA+ ATPase p97/VCP functions as an essential mediator of ubiquitin-dependent cellular processes, extracting ubiquitylated proteins from macromolecular complexes or membranes by catalyzing their unfolding. p97 is directed to ubiquitylated client proteins via multiple cofactors, most of which interact with the p97 N-domain.