Andreas Mund

Jan 14, 2025 | cell.com | Xiang Zheng |Andreas Mund |Matthias Mann

Keywords multiplexed imaging mass spectrometry deep visual proteomics spatial proteomics spatial medicine tumor microenvironment cancer immunotherapy tumor-infiltrating lymphocytes Introduction The tumor microenvironment (TME) is a complex ecosystem where cancer cells dynamically interact with diverse non-malignant cells, including immune cells, fibroblasts, and endothelial cells, as well as the extracellular matrix.1 These intricate interactions shape cancer progression and therapy...

Dec 5, 2024 | nature.com | Thierry M. Nordmann |Andreas Mund |Matthias Mann

Spatial mass spectrometry (MS)-proteomics is a rapidly evolving technology, particularly in the form of Deep Visual Proteomics (DVP), which allows the study of single cells directly in their native environment. We believe that this approach will reshape our understanding of tissue biology and redefine fundamental concepts in cell biology, tissue physiology and ultimately human health and disease.

May 23, 2024 | biorxiv.org | Xiang Zheng |Andreas Mund |Matthias Mann

AbstractDeciphering the intricate tumor–immune interactions within the microenvironment is crucial for advancing cancer immunotherapy. Here, we developed a novel approach integrating highly multiplexed imaging, laser microdissection, and deep visual proteomics (DVP) to spatially profile the proteomes of 21 distinct cell populations in human colorectal and tonsil cancers with high sensitivity.

Mar 18, 2024 | nature.com | Melanie Weisser |Andreas Mund |Blanca Lopez Mendez |Ivo A. Hendriks |Michael Nielsen |Hemmo Meyer | +2 more

AbstractThe hexameric AAA+ ATPase p97/VCP functions as an essential mediator of ubiquitin-dependent cellular processes, extracting ubiquitylated proteins from macromolecular complexes or membranes by catalyzing their unfolding. p97 is directed to ubiquitylated client proteins via multiple cofactors, most of which interact with the p97 N-domain.