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Mengyan Zhang

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Articles

  • A Thiopurine-like Mutagenic Process Defines TGCT Subtypes

    2 weeks ago | biorxiv.org | Kevin Brown |Jun Zhong |Adriana Miranda |Mengyan Zhang

    AbstractTesticular germ cell tumors (TGCTs) are the most common malignancy in young men, exhibit a unique developmental origin and exceptional chemosensitivity. However, the molecular distinctions between TGCT subtypes remain poorly understood. Here we present a comprehensive genomic analysis of 252 treatment-naive primary TGCTs, integrating deep whole-genome sequencing with matched transcriptomic and epigenomic data.

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