Mert Tokcan

1 month ago | nature.com | Mathias Hohl |Mert Tokcan |Jan M. Federspiel |Peter Boor |Markus Meyer |Felix Mahfoud

AbstractThe diuretic drug hydrochlorothiazide (HCT) is associated with an increased risk of non-melanoma skin cancer upon UV exposure. The underlying cellular and molecular mechanisms behind this association remain elusive. Herein, a human skin model to assess the photocarcinogenic effects of HCT is established. Skin biopsies collected from human body donors are treated with HCT and irradiated with 300 mJ/cm2 low dose UVA or UVB or with 5 J/cm2 high dose UVA.