Peter Boor

1 month ago | nature.com | Mathias Hohl |Mert Tokcan |Jan M. Federspiel |Peter Boor |Markus Meyer |Felix Mahfoud

AbstractThe diuretic drug hydrochlorothiazide (HCT) is associated with an increased risk of non-melanoma skin cancer upon UV exposure. The underlying cellular and molecular mechanisms behind this association remain elusive. Herein, a human skin model to assess the photocarcinogenic effects of HCT is established. Skin biopsies collected from human body donors are treated with HCT and irradiated with 300 mJ/cm2 low dose UVA or UVB or with 5 J/cm2 high dose UVA.

1 month ago | nature.com | Florian A. Rosenberger |Sophia C. Mädler |Katrine Holtz Thorhauge |Malin Fromme |Mikhail Lebedev |Marc Oeller | +7 more

AbstractProtein misfolding diseases, including α1-antitrypsin deficiency (AATD), pose substantial health challenges, with their cellular progression still poorly understood1,2,3. We use spatial proteomics by mass spectrometry and machine learning to map AATD in human liver tissue. Combining Deep Visual Proteomics (DVP) with single-cell analysis4,5, we probe intact patient biopsies to resolve molecular events during hepatocyte stress in pseudotime across fibrosis stages.

Jul 16, 2024 | nature.com | Peter Boor

Deep Learning (DL) holds great promise to improve patient outcomes by improving the precision and speed of disease diagnosis and treatment recommendations. Given the efficacy of DL in image analysis, pathology will likely be one of the first medical fields transformed by DL. However, several challenges must be overcome before we can expect to see the use of DL transform the digital future of pathology.

Nov 24, 2023 | science.org | Qian Bu |Yuki Takada |Manuel F. Ferrer-Garcia |Nadine Kaesler |Aurelien Dugourd |Julio Saez-Rodriguez | +4 more

Mapping cardiac remodeling in chronic kidney diseaseNadine Kaesler https://orcid.org/0000-0001-8097-7660, Mingbo Cheng https://orcid.org/0000-0003-3938-0461, [...] , James Nagai https://orcid.org/0000-0002-7655-7206, James O’Sullivan https://orcid.org/0009-0002-3425-6058, [...] , Fabian Peisker https://orcid.org/0000-0003-0123-8179, Eric M. J.