Miao Chen

Jan 14, 2025 | mdpi.com | Miao Chen |Huiran Liu |Han Wang |Zongyue Liu

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.

May 23, 2024 | nature.com | Miao Chen |Peng Liu

AbstractConcerted nucleophilic substitution, known as SN2 reaction, is a fundamental organic transformation used in synthesis to introduce new functional groups and construct carbon−carbon and carbon−heteroatom bonds1. SN2 reactions typically involve backside attack of a nucleophile to the σ* orbital of a C(sp3)−X bond (X= halogen or other leaving group), resulting in complete inversion of a stereocenter 2.

Feb 8, 2024 | cell.com | Miao Chen |Anhui Normal |Ziwei Zhang

Highlights•Electrically neutral probe with low MW, strong TP absorption, and large Stokes shift•Faster response, higher binding affinity, higher selectivity, and good BBB penetration•In situ visualize Aβ42 self-aggregation in cells and in vivo brain imaging for AD miceSummaryEfficient fluorescent probes for brain imaging of the progressive changes of amyloid-beta (Aβ) aggregates in Alzheimer’s disease (AD) are highly desired to track the occurrence and development of AD.

Nov 16, 2023 | onlinelibrary.wiley.com | Yusen Qiao |Lei Yu |Peng Yang |Miao Chen

1 Introduction Diabetes mellitus (DM) is a long-term metabolic disorder that affected ≈425 million people globally in 2017, and the number is estimated to surpass 629 million by 2035.[1] In addition to well-known macrovascular and microvascular complications, such as strokes, retinopathy, neuropathy, and nephropathy, patients suffering from DM have a higher risk of fractures than healthy individuals due to their disordered glucose metabolism and increased basal inflammatory levels in vivo.