Michael Curran

Ottawa

Publisher at Ottawa Business Journal

Publisher of Ottawa Business Journal, President of Great River Media, Supporter of Local Business & Entrepreneurs, Organizer of Events, Community Builder

Articles

Sickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity

3 weeks ago | cell.com | Zilong Zhao |Benxia Hu |Yalan Deng |Melinda Soeung |Jun Yao |Lanxin Bei | +25 more

Keywords sickle cell disease renal medullary carcinoma ferroptosis genomic architecture alteration Hi-C H2S SLC7A11 SMARCB1 immune checkpoint inhibitors CD8+ T cells Introduction Sickle cell disease (SCD), the most prevalent inherited blood disorder,1 arises from the homozygous HbS mutation (GAG>GTG: βGlu6Val), causing hemoglobin abnormalities that make red blood cells (RBCs) assume a sickle or crescent shape.2 Individuals with SCD have RBCs prone to hemolysis, leading to vaso-occlusive...
Sickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity

3 weeks ago | cell.com | Zilong Zhao |Benxia Hu |Yalan Deng |Melinda Soeung |Jun Yao |Lanxin Bei | +25 more

Keywords sickle cell disease renal medullary carcinoma ferroptosis genomic architecture alteration Hi-C H2S SLC7A11 SMARCB1 immune checkpoint inhibitors CD8+ T cells Introduction Sickle cell disease (SCD), the most prevalent inherited blood disorder,1 arises from the homozygous HbS mutation (GAG>GTG: βGlu6Val), causing hemoglobin abnormalities that make red blood cells (RBCs) assume a sickle or crescent shape.2 Individuals with SCD have RBCs prone to hemolysis, leading to vaso-occlusive...
Op-ed: Ottawa should brace itself for what could be harsh civil service cuts

1 month ago | obj.ca | Michael Curran

Since OBJ last went to press in December, the whole world has changed. At least it feels that way. Few could have predicted the political drama that would unfold in the first three months of 2025, with all the twists and turns of a Tom Clancy thriller: the forced resignation of the prime minister, the U.S. president’s decision to initiate a tariff war and question Canada’s sovereignty, the confirmation of Mark Carney as leader of the Liberals, and a snap general election. Pause here. Take a breath.
Rece Davis' NCAA Tournament Bracket Went Insanely Well

2 months ago | athlonsports.com | Michael Curran

Florida secured its third national championship with a 65-63 win over Houston on Monday night, capping off the 2025 NCAA Tournament. The Gators were a popular pick to win the national title when the bracket was released on Selection Sunday over three weeks ago, and they backed it up with an impressive six-game run to the title. ESPN's Rece Davis, the host of College Gameday, was among those who picked Florida to win the national championship.
Tim Tebow Reacts To Florida's National Championship Win

2 months ago | athlonsports.com | Michael Curran

Florida secured its third national title in men's basketball on Monday night with a 65-63 win over Houston. Despite trailing by as many as 12 points, the Gators fought back to topple the Cougars in the final minute of the game. Star guard Walter Clayton Jr. had a down night with just 11 points on 3-of-10 from the floor and 1-of-7 from three. However, Will Richard stepped up and led the Gators with 18 points including four three-pointers. Alex Condon also scored in double figures with 12 points.
Houston's First Post After Losing National Championship Heartbreaker to Florida

2 months ago | athlonsports.com | Michael Curran

Houston lost 65-63 to Florida in the national championship game on Monday night, concluding a Final Four that featured all four No. 1 seeds. The Cougars led by as many as 12 points, but they were unable to close out the Gators. Florida on the other hand never led by more than two points, but that was all it took in the end. Houston could not get a shot up on its final possession despite taking a timeout to draw something up.
Jay Williams Delivers Strong Take On Duke's Final Four Meltdown vs Houston

2 months ago | athlonsports.com | Michael Curran

The Duke Blue Devils lost in remarkable fashion on Saturday night, blowing a double-digit second-half lead and allowing Houston to close the game on an 11-1 run. Former Duke star and current ESPN basketball analyst Jay Williams appeared on SportsCenter shortly after the loss and provided his take on what went wrong for the Blue Devils and the magnitude of the loss. "This is probably the worst Duke loss that I think they've had in a long time," he said.
Jim Nantz Moved To Tears After Houston's Epic Final Four Comeback vs Duke

2 months ago | athlonsports.com | Michael Curran

After Houston pulled off its miraculous comeback against Duke in the Final Four on Saturday night, Jim Nantz, a 1981 graduate of the University of Houston, was emotional watching the Cougars celebrate from his courtside seat. Nantz even shed a few tears after witnessing Houston reach its first national title game since 1984. The former voice of the Final Four for CBS is a big fan of his alma mater and has already attended multiple games in this year's tournament.
Virginia Set To Hire Head Coach Who Led Historic No. 16 Seed Upset In NCAA Tournament

2 months ago | athlonsports.com | Michael Curran

When No. 1 seed Virginia fell to No. 16 seed UMBC in the opening round of the 2018 NCAA Tournament, it was a truly historic moment in college basketball history. A 16-seed had never defeated a No. 1 seed. The Cavaliers then redeemed themselves a year later and won the national championship. The story continues, however, as then-UMBC coach and current VCU coach Ryan Odom has been hired by Virginia, succeeding UVA's legendary coach Tony Bennett as the head man in Charlottesville.
Steph Curry Receives Major Injury Update Ahead of Warriors' Road Trip

2 months ago | athlonsports.com | Michael Curran

Golden State Warriors star Steph Curry received both good and bad news about his pelvic injury suffered against the Toronto Raptors on Friday. Curry is expected to miss time after an MRI revealed a pelvic contusion, according to a new report from ESPN's Shams Charania, but there is no structural damage. The Athletic's Anthony Slater also reported that Curry will not travel to Atlanta ahead of Golden State's matchup with the Hawks on Saturday.