Yalan Deng

1 month ago | cell.com | Zilong Zhao |Benxia Hu |Yalan Deng |Melinda Soeung |Jun Yao |Lanxin Bei | +25 more

Keywords sickle cell disease renal medullary carcinoma ferroptosis genomic architecture alteration Hi-C H2S SLC7A11 SMARCB1 immune checkpoint inhibitors CD8+ T cells Introduction Sickle cell disease (SCD), the most prevalent inherited blood disorder,1 arises from the homozygous HbS mutation (GAG>GTG: βGlu6Val), causing hemoglobin abnormalities that make red blood cells (RBCs) assume a sickle or crescent shape.2 Individuals with SCD have RBCs prone to hemolysis, leading to vaso-occlusive...

1 month ago | cell.com | Zilong Zhao |Benxia Hu |Yalan Deng |Melinda Soeung |Jun Yao |Lanxin Bei | +25 more

Keywords sickle cell disease renal medullary carcinoma ferroptosis genomic architecture alteration Hi-C H2S SLC7A11 SMARCB1 immune checkpoint inhibitors CD8+ T cells Introduction Sickle cell disease (SCD), the most prevalent inherited blood disorder,1 arises from the homozygous HbS mutation (GAG>GTG: βGlu6Val), causing hemoglobin abnormalities that make red blood cells (RBCs) assume a sickle or crescent shape.2 Individuals with SCD have RBCs prone to hemolysis, leading to vaso-occlusive...

Aug 14, 2024 | nature.com | Yalan Deng |Zilong Zhao |Yang Zhao |Chunru Lin |Fan Yao |Michael Curran | +1 more

AbstractLiver regeneration is under metabolic and immune regulation. Despite increasing recognition of the involvement of neutrophils in regeneration, it is unclear how the liver signals to the bone marrow to release neutrophils after injury and how reparative neutrophils signal to hepatocytes to reenter the cell cycle.

Jun 10, 2024 | nature.com | Yang Zhao |Yalan Deng |Shinichi Nakagawa |Fan Yao |Hai Wang

Correction to: Nature Communications https://doi.org/10.1038/s41467-024-46602-3, published online 16 March 2024The original version of this Article contained an error in Fig. 2b, in which the micro-CT image used as the representative image for male Malat1-/- in Fig. 2a was duplicated and presented as the representative image for the female Malat1+/+ mice. This error has been now corrected in both the PDF and HTML versions of the Article. All micro-CT images used to generate the plots in Fig.

Mar 16, 2024 | nature.com | Yang Zhao |Yalan Deng |Shinichi Nakagawa |Fan Yao |Hai Wang

AbstractMALAT1, one of the few highly conserved nuclear long noncoding RNAs (lncRNAs), is abundantly expressed in normal tissues. Previously, targeted inactivation and genetic rescue experiments identified MALAT1 as a suppressor of breast cancer lung metastasis. On the other hand, Malat1-knockout mice are viable and develop normally.