Michael Daniels

May 16, 2024 | biorxiv.org | Amy Lloyd |Anna Martinez-Muriana |Emma Davis |Michael Daniels

AbstractUsing high resolution quantitative mass spectrometry, we have generated the most comprehensive human and mouse microglia proteomic datasets to date, consisting of over 11,000 proteins across all six microglia groups. Microglia from different sources share a core protein signature of over 5600 proteins, yet fundamental differences are observed between species and culture conditions, indicating limitations for human disease modelling in mouse or in in vitro cultures of microglia.

Jun 22, 2023 | onlinelibrary.wiley.com | Michael Daniels |Minji Lee |Wei Feng

Abstract In longitudinal studies, it is not uncommon to make multiple attempts to collect a measurement after baseline. Recording whether these attempts are successful provides useful information for the purposes of assessing missing data assumptions. This is because measurements from subjects who provide the data after numerous failed attempts may differ from those who provide the measurement after fewer attempts.