Michael J. Ferracane

Sep 25, 2024 | pubs.acs.org | James Griffin |Michael J. Ferracane |Adam G Kreutzer |Jeramiah Small

This publication is Open Access under the license indicated. Learn MoreAddition/CorrectionSeptember 25, 2024*The Journal of Organic ChemistryCite this: J. Org. Chem. 2024, XXXX, XXXClick to copy citationCitation copied!correction. This publication is licensed under CC-BY-NC-ND 4.0 . You are free to share (copy and redistribute) this article in any medium or format within the parameters below:Creative Commons (CC): This is a Creative Commons license.

Sep 25, 2024 | dx.doi.org | James Griffin |Michael J. Ferracane |Adam G Kreutzer |Jeramiah Small

This publication is Open Access under the license indicated. Learn MoreAddition/CorrectionSeptember 25, 2024*The Journal of Organic ChemistryCite this: J. Org. Chem. 2024, XXXX, XXXClick to copy citationCitation copied!correction. This publication is licensed under CC-BY-NC-ND 4.0 . You are free to share (copy and redistribute) this article in any medium or format within the parameters below:Creative Commons (CC): This is a Creative Commons license.

Aug 3, 2023 | nature.com | Kayvon Pedram |Gabrielle S. Tender |Stacy A. Malaker |Caitlyn L. Miller |Kerriann Casey |Michael J. Ferracane | +1 more

AbstractTargeted protein degradation is an emerging strategy for the elimination of classically undruggable proteins. Here, to expand the landscape of targetable substrates, we designed degraders that achieve substrate selectivity via recognition of a discrete peptide and glycan motif and achieve cell-type selectivity via antigen-driven cell-surface binding. We applied this approach to mucins, O-glycosylated proteins that drive cancer progression through biophysical and immunological mechanisms.