Stacy A. Malaker

Nov 22, 2024 | dx.doi.org | Amanda Helms |Vincent Chang |Stacy A. Malaker |Jennifer S. Brodbelt

Nov 22, 2024 | pubs.acs.org | Amanda Helms |Vincent Chang |Stacy A. Malaker |Jennifer S. Brodbelt

May 10, 2024 | analyticalsciencejournals.onlinelibrary.wiley.com | Stacy A. Malaker

REFERENCES 1, , , , , . Recent advances in glycoinformatic platforms for glycomics and glycoproteomics. Curr. Opin. Struct. Biol. 2020; 62: 56-69. doi:10.1016/j.sbi.2019.11.009 2, , , et al. Glycoproteomics. Nat. Rev. Methods Primer. 2022; 2(1): 48. doi:10.1038/s43586-022-00128-4 3, , . Recent advances in mass spectrometry (MS)-based glycoproteomics in complex biological samples. TrAC Trends Anal. Chem. 2019; 118: 880-892. doi:10.1016/j.trac.2018.10.009 4, , . Towards structure-focused glycoproteomics.

Aug 3, 2023 | nature.com | Kayvon Pedram |Gabrielle S. Tender |Stacy A. Malaker |Caitlyn L. Miller |Kerriann Casey |Michael J. Ferracane | +1 more

AbstractTargeted protein degradation is an emerging strategy for the elimination of classically undruggable proteins. Here, to expand the landscape of targetable substrates, we designed degraders that achieve substrate selectivity via recognition of a discrete peptide and glycan motif and achieve cell-type selectivity via antigen-driven cell-surface binding. We applied this approach to mucins, O-glycosylated proteins that drive cancer progression through biophysical and immunological mechanisms.

Jul 14, 2023 | frontiersin.org | Stevan Springer |Stacy A. Malaker |Haci Mehmet Kayili

IntroductionImmune surveillance is a critical mechanism employed by our immune system to monitor for and protect against foreign agents posing health threats. The major histocompatibility complex (MHC) class I (MHC-I) and class II (MHC-II) molecules present repertoires of immunopeptides on the surface of cells, the immunopeptidome, by which T-cells can recognise abnormal or foreign peptide antigens, such as those of pathogen origin (1).