Michael J. Hawrylycz

Aug 1, 2024 | nature.com | Linus Manubens-Gil |Yufeng Liu |Alessandro Bria |Lei Qu |Lin Gu |Weidong Cai | +20 more

Correction to: Nature Methods https://doi.org/10.1038/s41592-023-01848-5, published online 17 April 2023. In the version of the article initially published, the Acknowledgements did not include thanks to H. Mansvelder (Vrije Universiteit Amsterdam), C. de Kock (Vrije Universiteit Amsterdam), R. Benavides-Piccione and J. DeFelipe (Instituto Cajal - CSIC). Additionally, Supplementary Table 1 has been updated to separate rows 27 and 28.

May 30, 2024 | thetransmitter.org | Holly Barker |Michael J. Hawrylycz

The brains of people missing a section of chromosome 22 show distinct connectivity patterns at different stages of development, according to a new preprint. And these altered connectivity patterns appear to be linked to changes at the synapse. Before adolescence, the brains of people lacking the chromosomal region 22q11.2 are hyperconnected compared with those of people without the condition, the preprint found.

May 29, 2024 | thetransmitter.org | Elissa Welle |Michael J. Hawrylycz |Jill Adams

The traditional story of Alzheimer’s disease casts two key proteins in starring roles—each with clear stage directions: Plaques of sticky amyloid beta protein accumulate outside neurons as the condition unfolds, and tangles of tau protein gum up the insides of the cells. But it may be time for a rewrite. Amyloid beta, too, coalesces inside neurons and seems to mark them for early death, according to research posted on a preprint server last November.

May 28, 2024 | thetransmitter.org | Michael J. Hawrylycz |Jill Adams

As a field, we’ve progressed in leaps and bounds in our ability to describe the brain’s cell types since pioneer neuroscientist Santiago Ramón y Cajal first used histological stains to visualize and classify neurons more than a century ago. Researchers now have an immense variety of data at hand—including anatomical, physiological, molecular and connectivity data—that can help classify brain cells.

May 22, 2024 | thetransmitter.org | Michael J. Hawrylycz |Jill Adams |Giorgia Guglielmi |Elissa Welle

Investigator Allen Institute for Brain Science Mike Hawrylycz joined the Allen Institute for Brain Science in Seattle, Washington, in 2003 as director of informatics and one of the institute’s first staff. His group is responsible for developing algorithms and computational approaches in the development of multimodal brain atlases, and in data analysis and annotation.