
Michel Bouvier
Articles
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Nov 29, 2024 |
lemonde.fr | Michel Bouvier
L’autonomie financière locale, modèle de gouvernance dans lequel s’enracinait la décentralisation, est en perdition. Ce modèle, qui associait autonomie fiscale (impôts spécifiques et vote des taux) et autonomie de gestion (globalisation de dotations et liberté d’utilisation des prêts) a pourtant été érigé en principe par la loi constitutionnelle de 2003. Mais ce n’était qu’une illusion juridique, car l’autonomie financière n’était déjà plus, à cette époque, que l’ombre d’elle-même.
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May 29, 2024 |
nature.com | Elk Kossatz |Rebeca Diez-Alarcia |Carla Ramon-Duaso |Suwipa Saen-Oon |Peter Kolb |Michel Bouvier | +2 more
AbstractG protein-coupled receptors (GPCRs) are sophisticated signaling machines able to simultaneously elicit multiple intracellular signaling pathways upon activation. Complete (in)activation of all pathways can be counterproductive for specific therapeutic applications. This is the case for the serotonin 2 A receptor (5-HT2AR), a prominent target for the treatment of schizophrenia.
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Nov 30, 2023 |
nature.com | Robert J. Lefkowitz |Howard A. Rockman |Paul J. Shim |Samuel E. Liu |Seungkirl Ahn |Sudarshan Rajagopal | +3 more
arising from T. Benkel et al. Nature Communications https://doi.org/10.1038/s41467-022-34765-w (2022)The introduction of β-adrenergic receptor blockers, “β-blockers”, as a treatment for heart failure decades ago was a major advance in cardiovascular medicine1,2,3,4. Moreover, it has been clear for a number of years that some β-blockers with “intrinsic sympathomimetic activity” (ISA) due to weak partial agonist activity mediated through G protein stimulation did not share this salutary effect5,6.
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