Rebeca Diez-Alarcia

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G protein-specific mechanisms in the serotonin 5-HT2A receptor regulate psychosis-related effects and memory deficits - Nature Communications

May 29, 2024 | nature.com | Elk Kossatz |Rebeca Diez-Alarcia |Carla Ramon-Duaso |Suwipa Saen-Oon |Peter Kolb |Michel Bouvier | +2 more

AbstractG protein-coupled receptors (GPCRs) are sophisticated signaling machines able to simultaneously elicit multiple intracellular signaling pathways upon activation. Complete (in)activation of all pathways can be counterproductive for specific therapeutic applications. This is the case for the serotonin 2 A receptor (5-HT2AR), a prominent target for the treatment of schizophrenia.

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