Suwipa Saen-Oon

May 29, 2024 | nature.com | Elk Kossatz |Rebeca Diez-Alarcia |Carla Ramon-Duaso |Suwipa Saen-Oon |Peter Kolb |Michel Bouvier | +2 more

AbstractG protein-coupled receptors (GPCRs) are sophisticated signaling machines able to simultaneously elicit multiple intracellular signaling pathways upon activation. Complete (in)activation of all pathways can be counterproductive for specific therapeutic applications. This is the case for the serotonin 2 A receptor (5-HT2AR), a prominent target for the treatment of schizophrenia.

Apr 6, 2024 | nature.com | Maria Martinez-Molledo |Paola Bartoccioni |Ignasi Puch-Giner |Camille Stephan-Otto Attolini |Rafael Artuch |Lucia Diaz | +6 more

AbstractRecent cryoEM studies elucidated details of the structural basis for the substrate selectivity and translocation of heteromeric amino acid transporters. However, Asc1/CD98hc is the only neutral heteromeric amino acid transporter that can function through facilitated diffusion, and the only one that efficiently transports glycine and D-serine, and thus has a regulatory role in the central nervous system.