Michelle Brennan

2 weeks ago | biorxiv.org | Rachel Weiss |Kelly D. Pyles |Kevin Cho |Michelle Brennan

AbstractHeart failure involves metabolic alterations including increased glycolysis despite unchanged or decreased glucose oxidation. The mitochondrial pyruvate carrier (MPC) regulates pyruvate entry into the mitochondrial matrix, and cardiac deletion of the MPC in mice causes heart failure. How MPC deletion results in heart failure is unknown.