Michelle Conti

Sep 19, 2024 | biorxiv.org | Michelle Conti |Rui Li |Lihua Zhu |Jillian P Bail

AbstractCell survival depends upon the ability to adapt to changing environments. Environmental stressors trigger an acute stress response program that rewires cell physiology, downregulates proliferation genes and pauses the cell cycle until the cell adapts. Here, we show that dynamic phosphorylation of the yeast cell cycle-regulatory transcription factor Hcm1 is required to maintain fitness in chronic stress.