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2 months ago | 
nature.com | Shahid Banday |Alok Mishra |Tianyi Ye |Junhui Li |Jason T. Yustein |Michelle Kelliher | +2 more
AbstractEwing sarcoma (ES) is an aggressive bone cancer driven by the oncogenic fusion-protein EWSR1::FLI1, which is not present in normal cells and is therefore an attractive therapeutic target. However, as a transcription factor, EWSR1::FLI1 is considered undruggable. Factors that promote EWSR1::FLI1 expression, and thus whose inhibition would reduce EWSR1::FLI1 protein levels and function, are potential drug targets.
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Jan 20, 2025 | 
lib.cam.ac.uk | Stuart Roberts |Lizzie Woodman |Lihua Zhu
Your libraries have you covered as you head into the New Year at Cambridge By Stuart Roberts and Lizzie Woodman Published January 21, 2025 get you confident exploring and using our electronic collections let you know how to access the Seeley Library collections during its temporary move into the West Room at Cambridge University Library alert you to new group study spaces at the UL enhance your study skills with our selection of training and workshops find out about our accessibility services...
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Jan 2, 2025 | 
mdpi.com | Lihua Zhu
3. Mechanism of Effector Protein TransportThe secretins of the T3SS are composed of three N-terminal N-domains (N0, N1, and N3) that extend into the periplasm, a C-domain that serves as the outer membrane entry point, and an S-domain where a specific piloting protein binds to the secretin, facilitating its localization and formation [].
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Dec 9, 2024 | 
mdpi.com | Xiaorui Zhang |Lihua Zhu |Libo Liu |Jialong Li
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Sep 19, 2024 | 
biorxiv.org | Michelle Conti |Rui Li |Lihua Zhu |Jillian P Bail
AbstractCell survival depends upon the ability to adapt to changing environments. Environmental stressors trigger an acute stress response program that rewires cell physiology, downregulates proliferation genes and pauses the cell cycle until the cell adapts. Here, we show that dynamic phosphorylation of the yeast cell cycle-regulatory transcription factor Hcm1 is required to maintain fitness in chronic stress.
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Sep 12, 2024 | 
lib.cam.ac.uk | VIcky Westmore |Vicky Westmore |Lihua Zhu
The iconic Stirling Building is home to the History Faculty and the Seeley Library, which holds collections for History, Politics & International Studies, Sociology, Land Economy, and Latin American Studies. The History Faculty moved into the Stirling building, designed by James Frazer Stirling, in 1968. The Stirling Building is a Grade II* listed building considered one of the best examples of modern post-war architecture in the UK.
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Aug 29, 2024 | 
mdpi.com | Yijia Guo |Lihua Zhu |Liyin Zhang |Xinxin Tang
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Jul 30, 2024 | 
lib.cam.ac.uk | VIcky Westmore |Vicky Westmore |Lihua Zhu
By Vicky Westmore30 July 2024 We will provide alternative ways to access electronic legal deposit content wherever possible, such as through inter-library loans and purchasing content. Legal deposit libraries have the right to request a copy of every publication in the UK and Ireland. Cambridge University Library has been collecting in print since 1710. Our print collection is ongoing and is still available.
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Jul 29, 2024 | 
mdpi.com | Duo Lv |Gang Wang |Jiaqi You |Lihua Zhu
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Jun 6, 2024 | 
lib.cam.ac.uk | Lihua Zhu |Lizzie Woodman
The Moonstone by Wilkie Collins The Moonstone foreshadowed many classic tropes of the twentieth-century detective novel: clues and red herrings; suspects and twists; investigations and reconstructions; and even an English country house. Moreover, it established the ethos of the genre: ingenuity; a fair, skilfully devised puzzle; and a deft shifting of suspicion. Bleak House by Charles Dickens An understanding of criminal psychology features significantly in Charles Dickens’s work.
