Michelle L. Ramseier

1 month ago | cell.com | Alan DenAdel |Michelle L. Ramseier |Andrew W. Navia |Alex K. Shalek |Srivatsan V. Raghavan |Peter Winter | +1 more

Keywordsclusteringdouble dippingsingle celldifferential expression analysiscalibrationmachine learningGet full text accessLog in, subscribe or purchase for full access. References1. Zheng, G.X.Y. ∙ Terry, J.M. ∙ Belgrader, P. ... Massively parallel digital transcriptional profiling of single cellsNat. Commun. 2017; 8, 140492. Macosko, E.Z. ∙ Basu, A. ∙ Satija, R. ... Highly parallel genome-wide expression profiling of individual cells using nanoliter dropletsCell. 2015; 161:1202-12143. Stoeckius, M.

Jun 10, 2024 | biorxiv.org | Peter Winter |Michelle L. Ramseier |Andrew W. Navia |Sachit Saksena

AbstractEfforts to cure BCR::ABL1 B cell acute lymphoblastic leukemia (Ph+ ALL) solely through inhibition of ABL1 kinase activity have thus far been insufficient despite the availability of tyrosine kinase inhibitors (TKIs) with broad activity against resistance mutants. The mechanisms that drive persistence within minimal residual disease (MRD) remain poorly understood and therefore untargeted.