Ming Sun

Nov 15, 2024 | genomemedicine.biomedcentral.com | Tongpeng Xu |Tian Tian |Chen Wang |Xiaofeng Chen |Xiangrong Zuo |Hanyu Zhou | +9 more

This was a researcher-initiated, single-arm, open-label, single-center, first-in-human clinical trial (ChiCTR2100046544) designed to evaluate the safety and efficacy of KT032 in patients with mesothelin-expressing advanced solid tumors between August 2021 and February 2024, at the First Affiliated Hospital of Nanjing Medical University. Tumor biopsies were evaluated for mesothelin (MSLN) expression at enrolment, followed by leukapheresis and KT032 manufacture.

Oct 9, 2024 | onlinelibrary.wiley.com | Yu Du |Xiankai Zhang |Ming Sun |Fei Long

1 INTRODUCTION Acute lymphoblastic leukaemia (ALL) is the most prevalent hematologic malignancy in children worldwide and a major cause of child mortality.1 B-cell ALL (B-ALL), a subtype of ALL, characterized by the rapid proliferation of immature B progenitor cells, or lymphoblasts, in the bone marrow (BM).2 Systemic chemotherapy, targeted therapy and sophisticated risk stratification have increased the 5-year survival rate to 90% in paediatric ALL.3, 4 Despite the significantly improved...

Sep 18, 2024 | digitalcommons.library.tmc.edu | Caishang Zheng |Yanjun Wei |Qiang Zhang |Ming Sun

The glioblastoma (GBM) stem cell-like cells (GSCs) are critical for tumorigenesis/therapeutic resistance of GBM. Mounting evidence supports tumor-promoting function of long noncoding RNAs (lncRNAs), but their role in GSCs remains poorly understood.

Sep 4, 2024 | mdpi.com | Ming Sun |Xinhua Wang |Wei Cui |Hongfang Liu

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Sep 3, 2024 | mdpi.com | Ming Sun |Xinhua Wang |Wei Cui

1. IntroductionMicroorganisms are commonly found in soil, fresh water, oil fields, and ocean environments. SRB, saprophytic bacteria (TGB), and iron-oxidizing bacteria (IOB) are the main microbial groups that cause the local corrosion of gathering and transportation pipelines in oil and gas fields. Among them, SRB are the most widely reported microbial group and have the most harmful impact on pipelines because they may cause pitting or cracking of pipelines [,,].