Minghao Xie

Aug 2, 2024 | sciencedirect.com | Reinhard Schweitzer-Stenner |Siobhan E. Toal |Minghao Xie |Tao Zhu

Section snippetsSignificanceThe expansion of G4C2 in the C9orf72 gene is a common genetic factor underlying familial amyotrophic lateral sclerosis and frontotemporal dementia, producing toxic dipeptide repeat proteins, notably polyPR. Despite its known toxicity, the mechanisms by which polyPR disrupts nucleocytoplasmic transport (NCT) remain debated. Our study, building upon recent research, reveals crucial insights.

Jun 16, 2023 | onlinelibrary.wiley.com | Zheng Li |Yangen Zhou |Minghao Xie

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Mar 29, 2023 | onlinelibrary.wiley.com | Zheng Li |Yangen Zhou |Minghao Xie

Graphical Abstract High-density cationic defects coupling with local alkaline-enriched environment were developed to inhibit the dissolution of highly active species during oxygen evolution reaction in alkaline solution. A higher concentration of alkaline around cationic defects than bulk electrolyte enables ultrafast diffusion of OH− ions. This novel strategy greatly enhances the stability and improves the activity.