Reinhard Schweitzer-Stenner

Jan 30, 2025 | mdpi.com | Reinhard Schweitzer-Stenner

This is an early access version, the complete PDF, HTML, and XML versions will be available soon.

Aug 2, 2024 | sciencedirect.com | Reinhard Schweitzer-Stenner |Siobhan E. Toal |Minghao Xie |Tao Zhu

Section snippetsSignificanceThe expansion of G4C2 in the C9orf72 gene is a common genetic factor underlying familial amyotrophic lateral sclerosis and frontotemporal dementia, producing toxic dipeptide repeat proteins, notably polyPR. Despite its known toxicity, the mechanisms by which polyPR disrupts nucleocytoplasmic transport (NCT) remain debated. Our study, building upon recent research, reveals crucial insights.

Jun 25, 2024 | nature.com | Reinhard Schweitzer-Stenner

AbstractThe influence of Hofmeister cations (NH4+, Na+, Mg2+) and anions (H2PO4−, CH3COO−, Cl−, NO3−) on the thermostability of a GHG hydrogel was investigated. The combined results of UV circular dichroism (UVCD) and Small Amplitude Oscillatory Shear Rheology experiments reveal that the addition of salt reduces the stability of the gel phase and the underlying fibrils.