Mounir Tarek

Jun 22, 2023 | frontiersin.org | Emigh Cortez |Mounir Tarek |Matthew Perry |Christopher Dempsey

1 IntroductionThe human ether-à-go-go-related gene (hERG) encodes voltage-gated potassium channel Kv11.1 that mediates the rapid repolarization phase during cardiac action potential (Sanguinetti and Tristani-Firouzi, 2006; Vandenberg et al., 2012). The hERG channel cycles between closed, open, and inactivated states in response to membrane voltage changes to tightly regulate K+ currents in the heart (Sanguinetti and Tristani-Firouzi, 2006; Vandenberg et al., 2012).