Nadeem Riaz

Sep 4, 2024 | nature.com | Manisha Jalan |Aman Sharma |Xin Pei |Yingjie Zhu |Melody Di Bona |Nadeem Riaz

AbstractCollisions of the transcription and replication machineries on the same DNA strand can pose a significant threat to genomic stability. These collisions occur in part due to the formation of RNA-DNA hybrids termed R-loops, in which a newly transcribed RNA molecule hybridizes with the DNA template strand. This study investigated the role of RAD52, a known DNA repair factor, in preventing collisions by directing R-loop formation and resolution.

Mar 12, 2024 | nature.com | Nadeem Riaz

AbstractMelanoma response to immune-modulating therapy remains incompletely characterized at the molecular level. In this study, we assess melanoma immunotherapy response using a multi-scale network approach to identify gene modules with coordinated gene expression in response to treatment.