David Brown

1 month ago | nature.com | Avantika Gupta |Fresia Pareja |David Brown |Yingjie Zhu |Juan Blanco-Heredia |Bojana Stefanovska | +11 more

AbstractAcquired genetic alterations drive resistance to endocrine and targeted therapies in metastatic breast cancer; however, the underlying processes engendering these alterations are largely uncharacterized. To identify the underlying mutational processes, we utilized a clinically annotated cohort of 3,880 patient samples with tumor-normal sequencing.

Aug 28, 2024 | mdpi.com | Safa Hamdare |David Brown |Yue Cao |Mohammad Aljaidi

1. IntroductionGovernments all over the world are supporting Electric Vehicles (EVs) to achieve the goals of cleaner transportation [1]. EVs play a vital role in lowering air pollution, reducing noise, and cutting carbon emissions compared to traditional vehicles running on fuel. For instance, the UK government plans to stop selling fuel-driven vehicles by 2030, with hybrids following in 2035, aiming to reach net-zero emissions by 2050 [2].

Mar 22, 2024 | medrxiv.org | Jennifer Hsu |Sandy Smith |David Brown |Benjamin Reardon

The authors have declared no competing interest. This study did not receive any fundingI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Ethics approval was obtained from Western Sydney Local Health District Research Office on 09/02/2022.

Oct 12, 2023 | nature.com | Kamel El Omari |Vitaliy Mykhaylyk |Christian M. Orr |Maria Romano |Luca Vecchia |Miki Senda | +10 more

AbstractDespite recent advances in cryo-electron microscopy and artificial intelligence-based model predictions, a significant fraction of structure determinations by macromolecular crystallography still requires experimental phasing, usually by means of single-wavelength anomalous diffraction (SAD) techniques. Most synchrotron beamlines provide highly brilliant beams of X-rays of between 0.7 and 2 Å wavelength.