Namasivayam Ambalavanan

Sep 11, 2024 | nature.com | Namasivayam Ambalavanan

CommentaryIn this month’s issue, Akangire et al. 1 characterize the clinical trajectory of bronchopulmonary dysplasia associated pulmonary hypertension (BPD-PH) in infants with ventilator-dependence at hospital discharge. As infants with BPD-PH are at increased risk for mortality2 and long term morbidity into adulthood,3 efforts to identify high risk subphenotypes4 are critical to improving outcomes in this population.

Jul 22, 2024 | digitalcommons.library.tmc.edu | Vivek Shukla |Benjamin Carper |Namasivayam Ambalavanan |Matthew A. Rysavy

HYPOTHESIS: Increased social distancing was associated with a lower incidence of extremely preterm live births (EPLB) during the initial COVID-19 pandemic period. STUDY DESIGN: Prospective study at the NICHD Neonatal Research Network sites comparing EPLB (22RESULTS: EPLB and EPIS percentages did not significantly decrease (1.58-1.45%, p = 0.07, and 0.08-0.06%, p = 0.14, respectively).

Feb 22, 2024 | nature.com | Sanjay Chawla |R. Laptook |Rachel Greenberg |Namasivayam Ambalavanan |Edward Bell |Susan R. Hintz | +1 more

AbstractTo compare the rates of death or survival with severe neurodevelopmental impairment (sNDI) at 2 years among extremely preterm infants in relation to pre-pregnancy or first-trimester maternal body mass index (BMI). This retrospective cohort study included extremely preterm infants (gestational age 220/7–266/7 weeks). The study was conducted at National Institute of Child Health and Human Development Neonatal Research Network sites. The primary outcome was death or sNDI at 2 years.

Jan 19, 2024 | nature.com | Namasivayam Ambalavanan

Acute chorioamnionitis is one of the most common causes of very preterm birth, thereby increasing the risk of adverse neonatal outcomes, including bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI).1 Despite recent advancements in neonatal care, the rates of BPD have increased for very preterm neonates, especially in those exposed to chorioamnionitis.2,3 The inflammation associated with chorioamnionitis is considered to be the primary driver of damage to developing...

Dec 29, 2023 | nature.com | Namasivayam Ambalavanan

Very preterm birth frequently results in extra-uterine growth restriction, often associated with various morbidities such as bronchopulmonary dysplasia, apnea of prematurity, sepsis, and episodes of feeding intolerance. This early struggle often casts a long shadow, impacting height and lean body mass into adulthood.