Susan R. Hintz

Jul 18, 2024 | digitalcommons.library.tmc.edu | Charles Green |Jon E. Tyson |Roy Heyne |Susan R. Hintz

OBJECTIVE: Extremely preterm (EP) impairment rates are likely underestimated using the Bayley III norm-based thresholds scores and may be better assessed relative to concurrent healthy term reference (TR) infants born in the same hospital. STUDY DESIGN: Blinded, certified examiners in the Neonatal Research Network (NRN) evaluated EP survivors and a sample of healthy TR infants recruited near the 2-year assessment age. RESULTS: We assessed 1452 EP infants and 183 TR infants.

Feb 22, 2024 | nature.com | Sanjay Chawla |R. Laptook |Rachel Greenberg |Namasivayam Ambalavanan |Edward Bell |Susan R. Hintz | +1 more

AbstractTo compare the rates of death or survival with severe neurodevelopmental impairment (sNDI) at 2 years among extremely preterm infants in relation to pre-pregnancy or first-trimester maternal body mass index (BMI). This retrospective cohort study included extremely preterm infants (gestational age 220/7–266/7 weeks). The study was conducted at National Institute of Child Health and Human Development Neonatal Research Network sites. The primary outcome was death or sNDI at 2 years.

Oct 31, 2023 | digitalrepository.unm.edu | Charles Green |Jon E. Tyson |Roy Heyne |Susan R. Hintz

AbstractOBJECTIVE: Extremely preterm (EP) impairment rates are likely underestimated using the Bayley III norm-based thresholds scores and may be better assessed relative to concurrent healthy term reference (TR) infants born in the same hospital. STUDY DESIGN: Blinded, certified examiners in the Neonatal Research Network (NRN) evaluated EP survivors and a sample of healthy TR infants recruited near the 2-year assessment age. RESULTS: We assessed 1452 EP infants and 183 TR infants.

Aug 4, 2023 | nature.com | Susan R. Hintz |Betty R. Vohr |Edward Bell |Andrea F. Duncan |Gary Myer |Matthew A. Rysavy | +4 more

We assessed Bayley III scores at two years adjusted age for EP infants and TR infants born in the same NRN centers and examined by the same assessors who had been trained to reliability [18] and were blinded to gestational age at birth, perinatal events, and prior follow-up findings. The mean composite cognitive, motor, and language scores were 83.9, 83.3, and 80.2, respectively, for the EP infants and 97.5, 98.2, and 97.9, respectively, for the TR group.

Jun 13, 2023 | acpjournals.org | Yair J. Blumenfeld |Susan R. Hintz |Richard Barth |Natali Aziz

Background: Cystic fibrosis (CF) is a life-shortening, autosomal recessive disease affecting approximately 150 000 people worldwide (1). The clinical manifestations of CF result from abnormalities in the cystic fibrosis transmembrane conductance regulator (CFTR) protein, and 80% to 90% of cases in populations of Northern European ancestry are due to a biallelic pathogenic variant (F508del) in the CFTR gene (2).