Nannan Zhang

3 weeks ago | pubs.acs.org | Jun Yu |Nannan Zhang |Jie Li |Huiyu Sun

Dec 18, 2024 | respiratory-research.biomedcentral.com | Guixiang Liu |Jing Wen |Chunyi Lv |Mingjie Liu |Nannan Zhang |Xuehua Li | +5 more

Consecutive patients with APE confirmed between January 2020 and September 2023, at 7 centers from China, were prospectively recruited. The inclusion criteria were as follows: (1) all patients who were diagnosed with APE on computed tomography pulmonary angiography (CTPA) or pulmonary ventilation perfusion (V/Q) scan [13]; (2) those aged > 18 years; (3) and those with complete imaging and clinical data and informed consent.

Sep 5, 2024 | dx.doi.org | Nannan Zhang |Jiaqi Hu |Wenlong Liu |Wenjun Cai

Sep 2, 2024 | nature.com | Lu Wang |Yujie Zhang |Caihong Wang |Yayuan Chen |Qian Qian |Nannan Zhang | +9 more

Depression, a widespread and highly heritable mental health condition, profoundly affects millions of individuals worldwide. Neuroimaging studies have consistently revealed volumetric abnormalities in subcortical structures associated with depression. However, the genetic underpinnings shared between depression and subcortical volumes remain inadequately understood. Here, we investigate the extent of polygenic overlap using the bivariate causal mixture model (MiXeR), leveraging summary statistics from the largest genome-wide association studies for depression (N = 674,452) and 14 subcortical volumetric phenotypes (N = 33,224). Additionally, we identify shared genomic loci through conditional/conjunctional FDR analyses. MiXeR shows that subcortical volumetric traits share a substantial proportion of genetic variants with depression, with 44 distinct shared loci identified by subsequent conjunctional FDR analysis. These shared loci are predominantly located in intronic regions (58.7%) and non-coding RNA intronic regions (25.4%). The 269 protein-coding genes mapped by these shared loci exhibit specific developmental trajectories, with the expression level of 55 genes linked to both depression and subcortical volumes, and 30 genes linked to cognitive abilities and behavioral symptoms. These findings highlight a shared genetic architecture between depression and subcortical volumetric phenotypes, enriching our understanding of the neurobiological underpinnings of depression. Depression affects millions of people worldwide. Here, the authors show a substantial polygenic overlap between depression and brain subcortical volumes, identifying 44 shared loci.

Aug 30, 2024 | mdpi.com | Pengfei Zhang |Ziwei Jiang |Xiaodong Wu |Nannan Zhang

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