Yujie Zhang

Dec 1, 2024 | jitc.bmj.com | Ling Wu |Rui Bai |Yujie Zhang |Hao Chen

Materials and methodsThe human CRC cell lines SW480 and HCT116 and the mouse CRC line MC38 were purchased from the Cell Bank of the Chinese Academy of Sciences (Shanghai, China). Cells were passaged three times and then cryopreserved. In each experiment, cells were cultured under standard culture conditions for 3–5 days after resuscitation until the cell density was 50–70%.

Nov 5, 2024 | mdpi.com | Mengjie He |Yujie Zhang |Yi Liu |Yang Shen

1. IntroductionContainer handling is a core aspect of port operations, requiring precise handling and strong safety awareness from operators, which directly impacts the successful delivery of goods. However, the frequent use of heavy machinery at container terminals often leads to accidents, resulting in severe economic losses, injuries, and even fatalities [1].

Sep 9, 2024 | morganlewis.com | George Cyriac |Widya Rianita |Yujie Zhang

SINGAPORE September 9, 2024: Morgan Lewis has advised AIGF Advisors Pte Ltd (“AIGF”) in its significant investment in Berjaya CKE International, a leading Malaysian commercial kitchen equipment manufacturer. The company manufactures its products in Malaysia, and markets them under its own brand, “Berjaya” in more than 40 countries.

Sep 2, 2024 | nature.com | Lu Wang |Yujie Zhang |Caihong Wang |Yayuan Chen |Qian Qian |Nannan Zhang | +9 more

Depression, a widespread and highly heritable mental health condition, profoundly affects millions of individuals worldwide. Neuroimaging studies have consistently revealed volumetric abnormalities in subcortical structures associated with depression. However, the genetic underpinnings shared between depression and subcortical volumes remain inadequately understood. Here, we investigate the extent of polygenic overlap using the bivariate causal mixture model (MiXeR), leveraging summary statistics from the largest genome-wide association studies for depression (N = 674,452) and 14 subcortical volumetric phenotypes (N = 33,224). Additionally, we identify shared genomic loci through conditional/conjunctional FDR analyses. MiXeR shows that subcortical volumetric traits share a substantial proportion of genetic variants with depression, with 44 distinct shared loci identified by subsequent conjunctional FDR analysis. These shared loci are predominantly located in intronic regions (58.7%) and non-coding RNA intronic regions (25.4%). The 269 protein-coding genes mapped by these shared loci exhibit specific developmental trajectories, with the expression level of 55 genes linked to both depression and subcortical volumes, and 30 genes linked to cognitive abilities and behavioral symptoms. These findings highlight a shared genetic architecture between depression and subcortical volumetric phenotypes, enriching our understanding of the neurobiological underpinnings of depression. Depression affects millions of people worldwide. Here, the authors show a substantial polygenic overlap between depression and brain subcortical volumes, identifying 44 shared loci.

Aug 5, 2024 | mdpi.com | Yujie Zhang |Xiaoyu Wang |Lei Zhang |Hongbin Xu

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