Lu Wang

Sep 2, 2024 | nature.com | Lu Wang |Yujie Zhang |Caihong Wang |Yayuan Chen |Qian Qian |Nannan Zhang | +9 more

Depression, a widespread and highly heritable mental health condition, profoundly affects millions of individuals worldwide. Neuroimaging studies have consistently revealed volumetric abnormalities in subcortical structures associated with depression. However, the genetic underpinnings shared between depression and subcortical volumes remain inadequately understood. Here, we investigate the extent of polygenic overlap using the bivariate causal mixture model (MiXeR), leveraging summary statistics from the largest genome-wide association studies for depression (N = 674,452) and 14 subcortical volumetric phenotypes (N = 33,224). Additionally, we identify shared genomic loci through conditional/conjunctional FDR analyses. MiXeR shows that subcortical volumetric traits share a substantial proportion of genetic variants with depression, with 44 distinct shared loci identified by subsequent conjunctional FDR analysis. These shared loci are predominantly located in intronic regions (58.7%) and non-coding RNA intronic regions (25.4%). The 269 protein-coding genes mapped by these shared loci exhibit specific developmental trajectories, with the expression level of 55 genes linked to both depression and subcortical volumes, and 30 genes linked to cognitive abilities and behavioral symptoms. These findings highlight a shared genetic architecture between depression and subcortical volumetric phenotypes, enriching our understanding of the neurobiological underpinnings of depression. Depression affects millions of people worldwide. Here, the authors show a substantial polygenic overlap between depression and brain subcortical volumes, identifying 44 shared loci.

Aug 6, 2024 | pubs.rsc.org | Huimin Wang |Lu Wang |Tao Wang |Ming Shen

Multifunctional Si3N4 nanobrick metasurface for sensing A metasurface composed of Si3N4 with a lower refractive index can result in more electromagnetic energy leaking into the surrounding environment compared with other dielectric materials, which is beneficial for sensing applications. However, the research on Si3N4 metasurfaces in the sensing field remains relatively scarce to date.

Jul 4, 2024 | onlinelibrary.wiley.com | Yonggang Wei |Lu Wang |Yi Tang |Junyue Su

Corresponding Author Yonggang Wei Chongqing Early Childhood Education Quality Monitoring and Evaluation Research Center, Chongqing Normal University, Chongqing, China Correspondence Yonggang Wei, Chongqing Early Childhood Education Quality Monitoring and Evaluation Research Center, Chongqing Normal University, No. 37 Middle Road, University Town, Gaoxin District, Chongqing 401331, China.

Jun 29, 2024 | scijournals.onlinelibrary.wiley.com | Yuning Gong |Lanyue Zhang |Jiahuan He |Baiyu Liu |Lu Wang |Yuhui Ao | +2 more

Supporting Information Filename Description pi6639-sup-0001-supinfo.docxWord 2007 document , 569.5 KB Data S1. Supporting Information. REFERENCES 1, , , , , et al., Chemosphere 311:137061 (2023). 2, , , , , et al., Macromolecules 55: 595–607 (2022). 3, and , Polym Sci D 8: 257–260 (2015). 4, , and , Prog Polym Sci 38: 1357–1387 (2013). 5, , and , React Funct Polym 165:104965 (2021). 6, , , , , et al., Chem Eng J 451:137823 (2023).

Jun 5, 2024 | nature.com | Guanshu Zhao |Juan Manuel Restrepo-Flórez |Andrew Wang |Chengliang Mao |Chaoran Li |Guangming Cai | +8 more

AbstractIndustrial-scale ethylene production occurs primarily by fossil-powered steam cracking of ethane—a high-temperature, high-energy process. An alternative, photochemical, pathway powered by sunlight and operating under ambient conditions could potentially mitigate some of the associated greenhouse gas emissions. Here we report the photocatalytic dehydrogenation of ethane to ethylene and hydrogen using LaMn1−xCuxO3.