Narmada Sambaturu

Nov 3, 2023 | biorxiv.org | Emily J. Fray |Fengting Wu |Carolin Zitzmann |Narmada Sambaturu

AbstractHIV can persist in a latent form as integrated DNA (provirus) in resting CD4+ T cells of infected individuals and as such is unaffected by antiretroviral therapy (ART). Despite being a major obstacle for eradication efforts, the genetic variation and timing of formation of this latent reservoir remains poorly understood. Previous studies on when virus is deposited in the latent reservoir have come to contradictory conclusions.