Nathan Rollins

Feb 21, 2024 | nature.com | David Ding |Nathan Rollins |Noam Prywes |David Savage |Michael T. Laub

AbstractRecent developments in protein design rely on large neural networks with up to 100s of millions of parameters, yet it is unclear which residue dependencies are critical for determining protein function. Here, we show that amino acid preferences at individual residues—without accounting for mutation interactions—explain much and sometimes virtually all of the combinatorial mutation effects across 8 datasets (R2 ~ 78-98%).

Jun 14, 2023 | biorxiv.org | David Ding |Ada Shaw |Nathan Rollins |Noam Prywes

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