Navid Paknejad

Nov 14, 2024 | nature.com | Shian Liu |Alexander Payne |Navid Paknejad |Edward T. Eng |Wei Liu |Yinglong Miao | +1 more

AbstractThe heart, in addition to its primary role in blood circulation, functions as an endocrine organ by producing cardiac hormone natriuretic peptides. These hormones regulate blood pressure through the single-pass transmembrane receptor guanylyl cyclase A (GC-A), also known as natriuretic peptide receptor 1.

Oct 28, 2023 | nature.com | Navid Paknejad |Richard K. Hite |Vinay Sapuru

AbstractInositol 1,4,5-trisphosphate receptors (IP3Rs) are endoplasmic reticulum Ca2+ channels whose biphasic dependence on cytosolic Ca2+ gives rise to Ca2+ oscillations that regulate fertilization, cell division and cell death. Despite the critical roles of IP3R-mediated Ca2+ responses, the structural underpinnings of the biphasic Ca2+ dependence that underlies Ca2+ oscillations are incompletely understood.

Aug 30, 2023 | nature.com | Shifra Lansky |Yining Jiang |Navid Paknejad |Crina M. Nimigean

AbstractTransient receptor potential (TRP) channels are a large, eukaryotic ion channel superfamily that control diverse physiological functions, and therefore are attractive drug targets1,2,3,4,5. More than 210 structures from more than 20 different TRP channels have been determined, and all are tetramers4.