Nazmiye Ozkan

May 29, 2024 | cell.com | Max Koppers |Nazmiye Ozkan |HA NGUYEN |ha nguyễn |Daphne Jurriens |Janine McCaughey | +7 more

Highlights•Axonal ER tubules are required for proper mRNA translation in axons•Nanoscale resolution imaging reveals ribosomes in contact with axonal ER tubules•The axonal ribosome receptor P180 binds specific mRNAs and controls local translation•Axonal ER-ribosome interactions are important for proper neuron developmentSummaryLocal mRNA translation in axons is critical for the spatiotemporal regulation of the axonal proteome.

May 16, 2024 | biorxiv.org | Nazmiye Ozkan |Max Koppers |Maarten A.F. Altelaar |Noortje Kersten

AbstractLysosomes are membrane-bound organelles critical for maintaining cellular homeostasis. Delivery of biosynthetic lysosomal proteins to lysosomes is crucial to orchestrate proper lysosomal function. However, it remains unknown how the delivery of biosynthetic lysosomal proteins to lysosomes is ensured in neurons, which are highly polarized cells.